The Great Pandolfo is a novel by William J. Locke that tells the story of Pandolfo, a talented musician who is forced to leave his home country of Italy and seek refuge in England due to a scandal. In England, Pandolfo struggles to make a living as a musician and ends up working as a waiter in a restaurant. However, his talent is eventually discovered by a wealthy woman named Lady Millingham, who becomes his patron and helps him achieve success as a musician. The novel explores themes of love, friendship, and the pursuit of artistic excellence.